Abstract
BackgroundProlonged and overlapping phases of wound healing in diabetes are mainly due to the redox imbalance resulting in the chronicity of the wound. Photobiomodulation therapy works on the principle of absorption of photon energy and its transduction into a biological response in the living tissue. It alleviates the cellular responses, thereby improving the mechanism of wound healing in diabetes.ObjectiveTo find out the effect of photobiomodulation therapy of dosage 4 J/cm2 in the healing dynamics of diabetic neuropathic wounds in Wistar rats and its relation with oxidative stress markers.MethodologyDiabetes was induced using Streptozotocin of 60 mg/kg of body weight to eighteen female Wistar rats. Neuropathy was induced by the sciatic nerve crush injury followed by an excisional wound of 2 cm2 on the back of the animal. Experimental group animals were treated with dosage 4 J/cm2 of wavelength 655 and 808 nm, and control group animals were kept unirradiated. The biomechanical, histopathological, and biochemical changes were analysed in both groups.ResultsThere was a reduction in mean wound healing time and an increased rate of wound contraction in the experimental group animals compared to its control group. The experimental group showed improved redox status, and histopathological findings revealed better proliferative cells, keratinisation, and epithelialization than un-irradiated controls.ConclusionsPhotobiomodulation therapy of dosage 4 J/cm2 enhanced the overall wound healing dynamics of the diabetes-induced neuropathic wound and optimised the oxidative status of the wound, thereby facilitating a faster healing process.
Highlights
Diabetes mellitus (DM) is a leading non-communicable disease in India and Globally
Foot ulcers occur in 15–25% of people with DM and between 5–7.5% of those with neuropathy [3]
There was a significant increase in the blood glucose (p = 0.015−6), water intake (p = 0.081−6), Urine Output (p = 0.039−6), and food intake (p = 0.039−6) by the end of the day-7. These symptoms are the classical triads of diabetes mellitus
Summary
Diabetes mellitus (DM) is a leading non-communicable disease in India and Globally. Individuals with DM suffer from microvascular and macrovascular complications that predispose them to develop conditions like cardiovascular diseases, peripheral vascular diseases, retinopathy, nephropathy, and peripheral neuropathy [1]. The global burden of DM affected nearly 463 million people in 2019 and is anticipated to rise up to 700 million by the end of 2045. During the 2019 survey, India reported the prevalence of 72 million people affected by DM and an anticipated increase of up to 153 million by 2045. Foot ulcers occur in 15–25% of people with DM and between 5–7.5% of those with neuropathy [3]. Photobiomodulation therapy works on the principle of absorption of photon energy and its transduction into a biological response in the living tissue. It alleviates the cellular responses, thereby improving the mechanism of wound healing in diabetes
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