Abstract
The effect of phenoxybenzamine (PBZ) on indomethacin (IM) induced systemic vasoconstriction was studied in 22 dogs using a right heart bypass procedure which allowed for control of cardiac output. Indomethacin alone (n = 8) caused an increase in mean arterial pressure (MAP) from 71 ± 6.5 mmHg to 116 ± 7.6 mmHg (p < .05). In PBZ pretreated dogs (n = 8) , the increase in MAP was from 49 + 3.4 mmHg to 80 ± 6.8 mmHg (p < .05). In 3 dogs given PBZ alone, MAP fell from 81 ± 7.3 mmHg to 42 ±3.8 mmHg (p < .05). In 3 untreated dogs, MAP fell from 86 ± 4.1 mmHg to 63 ± 9.0 mmHg. Thus, IM causes vasoconstriction in the systemic circulation of the dog, and this effects does not appear to be mediated by alpha adrenergic stimulation.
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