Abstract
AbstractThe stability of cefotetan disodium between the pH range 2-8 has been studied using a stability-indicating HPLC assay method. The optimum pH range of stability appears to be 3.6-6.4. At pH 2 or 8, the decomposition was approximately 2 times faster than between pH 3.6-6.4. The HPLC method used is accurate and precise with percent relative standard deviation of 1.0 based on 5 readings. The decomposition of cefotetan followed first-order law. The Kh and Koh values were estimated to be 3.8 and 4.4 × 104 d-1.
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