Effect of perioperative hypothermia therapy on elderly patients with acute intestinal obstruction

Abstract

Objective To investigate the effects of perioperative hypothermia therapy on immune function and nerve function recovery in elderly patients with acute intestinal obstruction. Methods From January 2010 to December 2015, 80 elderly patients with acute intestinal obstruction in the Traditional Chinese Medicine Hospital of Beilun District were selected and randomly divided into two groups, with 40 cases in each group.The control group was given conventional symptomatic treatment during operation, the observation group was given intraoperative hypothermia therapy on the basis of the control group.The CD4+ , CD8+ , CD4+ /CD8+ changes of immunoglobulin were observed in the two groups, the ESS(NIHSS) and Barthel index(daily life ability score) were compared between the two groups. Results After intervention, the CD4+ , CD8+ , CD4+ /CD8+ levels in the observation group were (35.1±2.0)%, (30.6±1.3)% and (1.9±0.3), respectively, which were higher than those in the control group[(26.0±0.9)%, (24.4±1.0)% and (1.6±0.2)], the differences between the two groups were statistically significant(t=26.242, 23.908, 5.262, all P<0.05). The IgM, IgG, IgA levels in the observation group were (1.60±0.03)g/L, (9.50±0.12)g/L, (3.90±0.20)g/L, respectively, which were higher than those in the control group[(1.30±0.02)g/L, (8.80±0.10)g/L, (1.80±0.15)g/L], there were statistically significant differences between the two groups(t=52.623, 28.342, 53.126, all P<0.05). The ESS, Barthel index in the observation group were (78.6±8.5), (77.3±6.6), respectively, which were higher than those in the control group[(59.6±6.1), (62.6±5.4)], there were statistically significant differences between two groups(t=11.486, 10.902, all P<0.05). Conclusion Hypothermia treatment can effectively reduce the effect of surgery on immune function in elderly patients with acute intestinal obstruction, promote the recovery of the nervous system, and improve the quality of life of the patients. Key words: Hypothermia, induced; Intestinal obstruction; Immunoglobulins; Aged