Abstract
The intestinal mucosal barrier plays an important role in systemic immune functions. This study aimed to find the mechanism of peptide from Alaska Pollock (APP) on intestinal mucosal immunity in mice induced by cyclophosphamide (Cy). Cy-induced decreases of body weight and index of immune organ were significantly improved by APP as compared with Cy group (p < 0.05). APP could promote the secretion of SIgA and IgA on intestinal mucosa (p < 0.05) and mainly had an impact on the final differentiation of IgA+ B cell, thereby promoting the secretion of plasma cells, which can be corroborated by the increases of IL-6 and IL-10 (p < 0.05). APP with high immune activity was separated and two peptides were purified and identified as Gly–Val–Ile–Lys and Ala–Cys–Asn–Gly–Arg. Therefore, APP can be considered as beneficial ingredients to protect the intestinal barrier disruption induced by Cy.
Highlights
Intestinal mucosal immunity, which is mainly composed of lymphocytes, macrophages, and plasma cells, is a natural barrier that provides the body’s first line of defense against potential damage from the environment [1]
Peptides with abundance of glutamine were frequently used to improve the immunity of the small intestine and the supplementation of branched-chain amino acid played an important role on the immune response [23,24]
According to the reference protein suggested by FAO/WHO [25], the chemistry scores of essential amino acids were more than 0.8, which indicated that Alaska Pollock Peptide (APP) can be used as a good source of quality protein
Summary
Intestinal mucosal immunity, which is mainly composed of lymphocytes, macrophages, and plasma cells, is a natural barrier that provides the body’s first line of defense against potential damage from the environment [1]. It is widely believed that the impaired intestinal barrier, following chemotherapy drugs, is responsible for the intestinal and systemic inflammatory responses and caused diarrhea, enteritis, and even systemic immunodeficiency which can lead to high mortality [2]. Is the major immunoglobulin of the small intestinal mucosa. SIgA is formed by the combination of pIgR, J-chain and α-chain (IgA) and is mainly secreted by mature plasma cells in small intestinal mucosa. The secretion of SIgA on small intestinal mucosa plays a leading role in maintaining intestinal homeostasis and the balance of immune system [5]
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