Abstract
ABSTRACT Zearalenone (ZEA) is a mycotoxin that is mainly produced by Fusarium fungi in food and feed. It causes many adverse effects on mammals, but there is little research on the effects of ZEA on intestinal mucosal immunity and intestinal flora in animals or humans. In this study, we aimed to explore the effects of short-term ZEA exposure on mucosal immunity and the microecological balance of the intestine. We found that the morphological structure of the intestinal mucosa in mice was severely destroyed after ZEA was administered by gavage for one week, and the mRNA expression levels of mucosal β-defensin, Mucin-1, Mucin-2, interleukin-1beta (IL-1β), and tumour necrosis factor-α (TNF-α) and secretory immunoglobulin A (sIgA) levels were significantly increased. In addition, the intestinal microflora was altered by ZEA. Our study showed that ZEA not only caused inflammation of the mucous membrane but also disturbed the microecological balance of the intestine in mice.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
