Effect of parecoxib sodium combined with ultrasound guided transversus abdominis plane block on efficacy of analgesia after gynecological laparoscopic surgery

Abstract

Objective To evaluate the efficacy of parecoxib sodium combined with ultrasound guided transversus abdominis plane (TAP) block for analgesia after gynecological laparoscopic surgery. Methods Sixty patients (45 to 65 years old, 53 - 72 kg and ASA grade Ⅰ or Ⅱ grade) who had underwent general anesthesia in laparoscopic hysterectomy were randomly divided into parecoxib group and control group, with 30 cases in each group two groups were in general anesthesia after tracheal intubation in. The ultrasound guided TAP block was performed in all patients after tracheal intubation in general anesthesia. After the operation, the control group was intravenously injected with 40 mg parecoxib sodium, and the control group was given 0.9% sodium chloride of the same volume. Operation time, pain visual scale (VAS) scores and body comfort scale (BCS) scores were recorded and compared. Results The levels of VAS scores in parecoxib sodium group were significantly lower than those in control group after 4, 8 and 24 h: (0.9 ± 0.2) scores vs. (1.9 ± 0.4) scores, (1.1 ± 0.4) scores vs. (2.7 ± 0.2) scores, (1.3 ± 0.3) scores vs. (3.1 ± 0.2) scores, and there were significant differences (P <0.05). The levels of BCS scores in parecoxib sodium group were significantly higher than those in control group after 4, 8 and 24 h: (2.9 ± 0.4) scores vs. (2.2 ± 0.3) scores, (2.8 ± 0.3) scores vs. (1.9 ± 0.4) scores, (2.6 ± 0.5) scores vs. (1.7 ± 0.4) scores, and there were significant differences (P<0.05). Conclusions Parecoxib sodium combined with ultrasound guided TAP block for analgesia after gynecological laparoscopic surgery can provide a good analgesic effect. Key words: Abdominal muscles; Nerve block; Ultrasonography; Analgesia; Randomized controlled trial