Effect of parecoxib on wound healing in early third degree burn in mice

Abstract

Objective To evaluate the effect of parecoxib on wound healing in the early third degree burn in mice. Methods Ninety ICR male mice, aged 6–8 weeks, weighing 20–25 g, were randomly divided into 3 groups (n= 10 each) using a random number table: burn group (B group); low-dose parecoxib group (LP group); high-dose parecoxib group (HP group). In LP and HP groups, at 4 h after Ⅲdegree burn model was established, parecoxib 0.75 mg/kg and 7.50 mg/kg were injected intraperitoneally, respectively, every 24 h (administration 3 times in total). The equal volume of normal saline 0.5 ml was given in group B. Ten rats were sacrificed at 24 h after each administration (T1-3), the tissues from and around the burn wound were obtained and observed for microscopic examination (under light microscope), and for determination of endothelial marker factor Ⅷ-related antigen expression, and microvessel count. Results Compared with group B, no significant change was found in inflammatory responses in the wound at each time point in group LP, and the inflammatory responses in the wound were significantly alleviated at T3, and the wound healing was better in group HP.Compared with group B, the microvessel count was significantly increased at T3 (P 0.05). Conclusion Parecoxib 7.50 mg/kg can promote wound healing in the early third degree burn in mice. Key words: Cyclooxygenase inhibitors; Burns; Wound healing