Clinical observation of modified chitin combined with recombinant human basic fibrolast growth factor in treating superficial partial-thickness burn wound

Abstract

Objective To observe the therapeutic effect of modified chitin combined recombinant human basic fibrolast grouth factor (rh-bFGF) on superficial partial-thickness burn wounds. Methods Eighty cases of Superficial partial-thickness burns from the department of Burns and Plastic Surgery, First Hospital of Shijiazhuang from November 2015 to August 2017 were divided into the treatment group and the control group according to the random number table method, 40 cases in each group. The treatment group patients′ wounds were first sprayed with rh-bFGF, then covered with modified chitin, and routinely prevented infection treatment. The dressing was changed once a day until the wounds healed. After cleaned the wounds of control group, externally modified chitin was used to cover the wounds and the dressing was changed once a day. The average wound healing time, wound healing rates of patients on 7, 10 and 13 days after injury, wound infection status, scar condition, patient dressing pain index, and other adverse reactions were observed. The t-test was used to compare the average wound healing time, the healing rates of wounds at different time, and the patient′s dressing pain index. Results The average healing time in the treatment group was (11.55±2.02)d, which was shorter than the [(12.63±1.96) d]of control group, the difference was statistically significant (t=2.41, P=0.02). The healing rates in the treatment group at 7, 10, 13 days were (86.00±4.28)%, (95.53±3.65)% and (99.55±0.68)%, those were higher than the control group[(84.23±3.38)%, (93.50±3.21)% and (99.10±1.06)%], the differences were statistically significant (t=2.06, 2.63, 2.27; P=0.04, 0.01, 0.03). The numerical rating score (NRS) of patients in the treatment group was (3.46±0.51) points, and in the control group was (3.50±0.50) points, there was no statistically significant difference (t=0.27, P=0.78). No infection occurred in both groups during the treatment, and no scar hyperplasia was observed in the follow-up 3 months. No other adverse reactions were found. Conclusion The use of modified chitin combined with rh-bFGF can significantly shorten the wound healing time and increase the wound healing rate in patients with superficial second degree burns, and no other adverse reactions were found. Key words: Fibrolast growth factor; Burns; Wound healing; Chitin