Abstract
IntroductionAdministration of biphosphonates in patients with renal failure requires a dosage adjustment. ObjectivesAnalyse renal function evolution in multiple myeloma patients after reducing infusion time for 90mg pamidronate by 2h. MethodsIn 2007, a retrospective study was carried out on all patients who presented multiple myeloma and bone metastasis treated with pamidronate administered every 4h. Following a review of the literature, a protocol for administering pamidronate every 2h was created in partnership with Haematology, and a specific dose reduction framework was established for patients with baseline renal failure. Additionally, a prospective follow-up study of those patients’ renal function was completed to analyse its evolution after the change in infusion time. ResultsA total of six patients received 90mg pamidronate every 4h. 33.32% of the patients (2/6) presented baseline renal insufficiency, and therefore needed to have the pamidronate dose adjusted according to the new protocol. Subsequently, all of them received the treatment every 2h, and one patient (16.6%) experienced altered renal function after two treatment cycles. DiscussionReducing administration time for pamidronate from four to 2h did not lead to significant variations in patients’ renal function. This therapeutic practice can improve patients’ quality of life by shortening their hospital stay without aggravating their renal function.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call