Abstract
After a 3-day administration of oxytetracycline and chloramphenicol, respectively, to rats an approximately dose-dependent decrease in the pancreatic secretion of proteins and enzyme activities was demonstrable in vivo under exogenous stimulation. The volume and electrolyte output of the pancreatic secretion were found to remain essentially unchanged. Since short-term administration of these antibiotics did not produce any alteration in exocrine pancreatic function, an impairment in enzyme synthesis is suggested as the major cause of the observed change in secretion.
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