Abstract
This study aimed to investigate the effect of estrogen withdrawal on bone tissue in adult female marmoset monkeys. In a 1-year follow-up study we used quantitative computer tomography to measure total bone mineral density (BMD) of the proximal tibia and the second-last lumbar vertebral body (L5/L6) before and 1, 3, 6, and 12 months after ovariectomy. Body mass did not significantly change during the 1-year observation period. However, a significant decline of total BMD after ovariectomy was observed in the proximal tibia but not in L5/L6. In addition, regression analysis showed a significant positive relationship between BMD and body mass in both tibia and L5/L6. The results of our study support the idea that ovariectomized marmoset monkeys may serve as a model to investigate bone loss related to decline of estrogen production.
Highlights
More than 70 years ago the link between bone loss and estrogen depletion in women was first described (Albright et al, 1940; Reifenstein and Albright, 1947)
In the Guideline on the evaluation of new medical products in the treatment of primary osteoporosis published by the European Medicines Agency (EMEA; see http://www.emea.europa.eu/ pdfs/human/ewp/055295en.pdf, last access: 24 June 2019) it is stated that new substances for treatment of postmenopausal osteoporosis should be tested in at least two species, one of which should be the ovariectomized rat and the other a mammal with evaluable cortical bone remodeling
The two main results of this investigation are that (1) female marmoset monkeys lose bone mass in the proximal tibia within 1 year after ovariectomy (Figs. 4b and 5) but not in the lumbar vertebra (Figs. 4d and 5) and that (2) body mass is a strong predictor of bone mass in the lumbar vertebrae and in the tibia
Summary
More than 70 years ago the link between bone loss and estrogen depletion in women was first described (Albright et al, 1940; Reifenstein and Albright, 1947). In a recent paper it was suggested that orchidectomized male common marmosets are a suitable model to study the development of bone mineral loss related to androgen deficiency (Seidlová-Wuttke et al, 2008) This result is supported by the findings that both osteonal remodeling and bone metabolism are similar to that of humans (Angeliewa et al, 2004; Bagi et al, 2007; Grohmann et al, 2012) and the antiosteoporosis drugs ibandronate (Angeliewa et al, 2004) and alendronate (Bagi et al, 2007) increase bone mass in intact marmosets
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
