EFFECT OF ORANGE PEEL EXTRACT ON INTESTINAL ABSORPTION OF ASPIRIN USING EVERTED SAC TECHNIQUE

Abstract

Drug distribution and absorption are significantly influenced by the biological membrane's permeability. Since aspirin requires high and frequent doses and undergoes substantial presystemic metabolism during oral absorption, there is a higher risk of GIT adverse effects. The purpose of the current study was to use the everted sac technique on goat intestine to examine the impact of orange peel (Citrus Aurantium Dulcis) extract on intestinal absorption. When kept with orange peel extract, the concentration of absorbed aspirin was 20, 26, 30, 38, and 50μg/ml after 15, 30, 45, 60, and 75 minutes, compared to 14, 16, 17, 18 and 23 μg/ml when kept alone. According to the study, aspirin is absorbed more readily from goat intestines when orange peel extract is used. Citrus peel contains a lot of phenolic chemicals, including flavonoids and phenolic acids. In addition, limonene, citral, neohesperidin, naringin, rutin, rhamnose, eriocitrin, and Vitamin-C etc. are found in the peel. They might be in charge of the plant's capacity to boost absorption.