Abstract
Thyroidal I131 uptake and serum protein-bound iodine concentration were measured before and at intervals after the administration of Lipiodol by mouth to euthyroid subjects. The thyroidal I131 uptake was depressed for 445 days (the duration of the study) after ingestion of Lipiodol. The serum proteinbound iodine level was first markedly elevated, fell rapidly during the first three to four months, and then very slowly approached normal. The serum free iodine level remained high in 2 of 4 subjects for 445 days. These findings indicate that Lipiodol is readily absorbed from the intestinal tract, is stored in an unknown site, and its iodine is slowly released in amounts sufficient for binding with the serum proteins and for suppression of the thyroidal I131 uptake.
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