Abstract
Recent animal studies found the potential of a collagen peptide derived from skate skin to have anti-obesity effects through the suppression of fat accumulation and regulation of lipid metabolism. However, no studies have yet been performed in humans. Here, this very first human randomized, placebo-controlled, and double-blinded study was designed to investigate the efficacy and tolerability of skate skin collagen peptides (SCP) for the reduction of body fat in overweight adults. Ninety healthy volunteers (17 men) aged 41.2 ± 10.4 years with a mean body mass index of 25.6 ± 1.9 kg/m2 were assigned to the intervention group (IG), which received 2000 mg of SCP per day or to the control group (CG) given the placebo for 12 weeks and 81 (90%) participants completed the study. Changes in body fat were evaluated using dual energy X-ray absorptiometry as a primary efficacy endpoint. After 12 weeks of the trial, the percentage of body fat and body fat mass (kg) in IG were found to be significantly better than those of subjects in CG (−1.2% vs. 2.7%, p = 0.024 and −1.2 kg vs. 0.3 kg, p = 0.025). Application of SCP was well tolerated and no notable adverse effect was reported from both groups. These results suggest the beneficial potential of SCP in the reduction of body fat in overweight adults.
Highlights
The global burden of cardiovascular diseases (CVD), which is the most common cause of death is increasing rapidly despite tremendous treatment options for diabetes, hypertension and dyslipidemia [1]
Compliance was satisfactory with participants taking more than 90% of the supplements given in both intervention group (IG) and control group (CG)
The molecular mechanism underlying the anti-obesity effect of fish collagen peptides has been discovered, the influence of them on body fat in humans had yet to been addressed before our study
Summary
The global burden of cardiovascular diseases (CVD), which is the most common cause of death is increasing rapidly despite tremendous treatment options for diabetes, hypertension and dyslipidemia [1]. Obesity is the root cause of chronic diseases that have been afflicting about one-third of the total population globally and the crucial factor to solve for prevention of fatal health issues [3]. Medical experts have been struggling to find out effective treatment options for obese people, there have been only a few medications used to suppress appetite by working on the. Mar. Drugs 2019, 17, 157; doi:10.3390/md17030157 www.mdpi.com/journal/marinedrugs. Mar. Drugs 2019, 17, 157 central neurologic system, which often brings about unexpected side effects such as the urge of suicide, aggravation of depression or other psychological issues [4]. It is necessary to discover a material with an anti-adipogenic effect to help lose weight that comes from naturally available sources without any concerns of side effects
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