Effect of oral clonidine and tizanidine on the induction dose of propofol and intubation response in general anesthesia

Abstract

Background: Laryngoscopy and tracheal intubation are associated with hemodynamic and cardiovascular responses consisting of increased heart rate, blood pressure and tachycardia and dysarrhythmias. The alpha2-adrenoreceptor agonists such as clonidine and tizanidine have several beneficial actions during the perioperative period. They improve hemodynamic stability in response to endotracheal intubation and surgical stress. Objective: To study the effect of oral clonidine and tizanidine on induction dose of propofol and hemodynamic responses after laryngoscopy in patients undergoing surgery under general anesthesia Methods: Hundred patients in age group of 18-70 years old of ASA 1/2 undergoing elective surgeries under general anesthesia with tracheal intubation was included in the study. Tizanidine 4 mg prescribed to group A, 0.1 mg clonidine to group B 60 min before the time of induction or laryngoscopy. systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and heart rate recorded before induction, pre-intubation, after intubation at 0 min, and then at interval of 1,3,5 minute after laryngoscopy by an independent observer.