Abstract
Purpose: Single dose intravenous omeprazole does not affect oesophageal motility but famotidine increases the lower oesophageal sphincter (LOS) pressure but has no effect on the oesophageal motility. We studied the effect of multiple doses of oral Omeprazole on the LOS pressure and oesophageal motility. Methods: We studied 16 healthy asymptomatic volunteers (21–50 years, 14 males). None was on any medications. All had normal Ultrasound examination of the abdomen. We performed static perfusion oesophageal manometry (OM) using continuous water perfusion system (Redtech, GiPC, CA). Amplitude (Uamp), duration (Udur) and velocity (Uvel) of upper oesophagus (20 cm above LOS) and amplitude (Lamp), duration (Ldur) and velocity (Lvel) of lower oesophagus (5cm above LOS), Resting presure (RP) and relaxation of LOS (RLOS) were studied. Studies were performed as baseline OM and after 3 days of Omeprazole 20mg b.i.d. The investigator was blinded to subject status vis a vis baseline or post drug. Ethical requirements were followed. Statistical analysis was done using t-test for paired samples. Results: The manometry findings were [mean (SD)]: Baseline Post drug Uamp (mmHg) 17.6 (9.2) 17.23 (10.9) Udur (sec) 2.27 (1.0) 2.30 (1.03) Uvel (cm/s) 2.36 (0.8) 2.35 (0.73) Lamp (mmHg) 46.3 (35) 53.2 (36.3) Ldur (sec) 4.56 (1.5) 4.59 (1.62) Lvel (cm/s) 3.48 (1.8) 3.97 (2.55) RP (mmHg) 24.3 (12) 26.9 (10.2) (p = 0.025) RLOS (%) 97.1 (4.9) 97.06 (4.79) Conclusions: Omeprazole significantly increased Lower oesophageal sphincter resting pressure in healthy volunteers. We report another property of Omeprazole that may have implications in treatment of upper GI disorder.
Published Version
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