Abstract
The effect of ochratoxin A on the carbohydrate metabolism of liver has been investigated in rats. A marked depletion of glycogen in liver and an increase of serum glucose in ochratoxin A-treated rats were noted. Glycogen synthetase (I and total) activities were reduced. In contrast, phosphorylase a activity was increased in the liver of ochratoxin A-treated rats. Decrease in incorporation of [ 14C]-glucose into hepatic glycogen confirmed the findings using unlabeled glucose. These results implied that depletion of hepatic glycogen in ochratoxin A-treated rats was attributed to the inhibition of the active transport of glucose into liver tissue, suppression of glycogenesis, and acceleration of glycogenolysis.
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