Abstract
1. Effects of acetaminophen and sodium salicylate on hydoxyl radical elimination were studied using an electron-spin-resonance spin-trapping method. The effects of these agents on lipid peroxidation of the human erythrocyte membrane were also investigated by the thiobarbituric acid method. 2. Acetaminophen and sodium salicylate depressed hydroxyl radical generated by Cu 2+/H 2O 2. 3. Acetaminophen inhibited Cu 2+/H 2O 2-dependent lipid peroxidation; however, sodium salicylate enhanced Cu 2+/H 2O 2-dependent lipid peroxidation.
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