Effect of Nonionic Surfactants on the Transport of Testosterone across a Cellulose Acetate Membrane

Abstract

Solubilization of testosterone by a series of three alkylpolyoxyethylene surfactants at 37° has been examined as a function of surfactant concentration. The effect of these surfactants has also been investigated upon the diffusion of testosterone through cellulose acetate membranes. Diffusion coefficients were calculated using a method that allows the measurements to be completed in a very short time. Possible mechanisms by which surfactants may affect drug transport are discussed. In all cases examined, the surfactants reduced the diffusion coefficient of testosterone.