Abstract
Objectives: A Disintegrin -like and Metalloproteinase with Thrombospondin-1 (ADAMTS-1) is a protease with structure similar to Matrix metalloproteinase. ADAMTS-1 has role in wound healing, fibroblast migration, tissue modeling, vasculogenesis and development of neuronal system. The levels of ADAMTS-1 vary in periodontal health and disease. To evaluate the effect of Non-Surgical Periodontal Therapy (NSPT) on salivary and serum ADAMTS-1 levels in generalized periodontitis patients. Methodology: Forty-five subjects suffering from generalized periodontitis were selected and periodontal parameters were assessed using periodontal probing depth (PPD) and clinical attachment level (CAL). Salivary and serum ADAMTS-1 levels were assessed using enzyme-linked immunosorbent assay. NSPT was performed involving scaling and root planning, followed by oral hygiene instructions. The patients were recalled after three months, periodontal parameters and ADMATS-1 levels were analyzed. Pre- NSPT levels of periodontal parameters and ADAMTS-1 levels were compared with post NSPT. Descriptive statistics and paired t-test were applied to compare the variables. P-value < 0.05 was considered statistically significant. Results: Serum ADAMTS-1 levels pre NSPT was 119.45ng/L and elevated post NSPT to 143.43ng/L. The salivary ADAMTS-1 at baseline was 157.81 and post NSPT 161.53 ng/L and both the values were statistically significant post NSPT.
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