EFFECT OF NIMODIPINE AND DICLOFENAC IN EXPERIMENTALLY INDUCED CONVULSIONS USING INH AND ELECTRO CONVULSOMETER IN RATS AND MICE

Abstract

Aim: The study aims to evaluate the anticonvulsant effect of Nimodipine and combined effect of Nimodipine and Diclofenac in experimentally induced seizures in Rats and Mice taking distilled water as control. Material and methods : Male wistar rats weighing 150-180gms and albino mice of average weight 20-30gms were used.All the preparations were administered intraperitoneally. Convulsions were induced electrically by electroconvulsometer and chemically by INH. The following parameters with electrically induced convulsions are recorded. a)duration of convulsions, b)duration of hind limb extension, c)post ictal depression followed by recovery. With chemically induced convulsions using INH the following parameters are recorded a)onset of convulsions, b)type of convulsions, c)duration of convulsions. Distilled water is used as control. Drugs are given 30 minutes before the electrically and chemically induced convulsions. Effect of Nimodipine and combined effect of Nimodipine and Diclofenac were studied. Results : Nimodipine has reduced the duration of convulsions, hind limb extension, delayed the onset of convulsions and recovery from postictal depression was fast from electric shock. Combined effect of Nimodipine and Diclofenac has an improved effect in duration of convulsions, hind limb extension and recovery when compared with that of Nimodipine alone. Observation: Statistic ANOVA test show significant P value <0.0001 in electrical method and chemical method .The results obtained in this study provide supporting pharmacological evidence of improved efficacy possible potential benefit of combining Nimodipine with Diclofenac in epilepsy. Keywords: Isoniazid(INH), Nimodipine with Diclofenac in epilepsy, anticonvulsant effect, improved effect in duration of convulsions