Abstract
Nicotine produced a significant increase in the release of 3H-NE from incubated slices prepared from rat hypothalamus, cortex, and cerebellum. The effect on the hypothalamus was much greater than on the other two regions. Nicotine also produced a release of 3H-NE from superfused slices of rat hypothalamus which was dependent upon extracellular calcium and reduced by prior addition of hexamethonium or acetylcholine to the superfusion medium. Nicotine produced a similar release of 3H-DA from rat striatal slices. This effect was reduced by acetylcholine, methacholine, hexamethonium and lidocaine. Morphine and cocaine were without effect while phenoxybenzamine produced a significant increase in the release of 3H-DA induced by nicotine. It is concluded that nicotine can release monoamines from central tissue; the effect is dependent upon extracellular calcium and is produced by an action on classical nicotinic receptors. In addition, this study provides support for the muscarinic inhibitory hypothesis suggesting that acetylcholine may modulate the release of DA and NE from central neurones in a similar way as NE from peripheral adrenergic neurones.
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