Abstract
This chapter elaborates the effect of acetylcholine on the release of 3H-norepinephrine by nicotine, and potassium chloride from rat brain slices. Studies were carried out in Sprague–Dawley rats weighing 150–200 g. The effect of nicotine in a concentration of 1 mM on the release of 3H-NE from the superfused slice of rat hypothalamus alone, and in the absence of extracellular Ca2+, and presence of acetylcholine is shown. It can be seen that nicotine produces a marked increase in the efflux of 3H-NE which is blocked by the removal of extracellular Ca2+, or in the presence of acetylcholine. A similar effect is seen in slices obtained from the cerebellar cortex when potassium chloride is the releasing agent. The present data is quite consistent with observations made on peripheral adrenergic neurons, and suggests that acetylcholine can decrease the release of NE to depolarizing, and pharmacological influences from neurons in the central nervous system.
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