Abstract
Gestational diabetes mellitus (GDM) is a disease with abnormal blood glucose for the first time in gestation, and its main harm is vascular lesions, usually diabetic kidney damage. A new glucose ligand modified neutrophil-like cell membrane coated melanin nanoparticle (Melanin@Glc-NCM) was designed and prepared. Through the results of cell and animal experiments the research confirmed that under near-infrared irradiation, Melanin@Glc-NCM achieved excellent kidney-targeted drug delivery. In addition, the results of photothermal therapy in diabetic nephropathy of gestational rats demonstrated that Melanin@Glc-NCM could promote glomerular mesangial cell (GMC) apoptosis and restrain GMC hyperproliferation after near-infrared irradiation to protect the kidney as a therapeutic drug for diabetic nephropathy of gestational rats.
Published Version
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