Abstract
ABSTRACT Nabumetone is used to reduce the pain and inflammation in rheumatoid arthritis. In the current study, immunomodulatory effect of Nabumetone is investigated in mice. The control group was administered normal saline orally as placebo. Nabumetone was administered orally via gavage in two treatment groups at 14mg/kg.b.w. doses and 28mg/kgb.w., respectively. Haemagglutination (HA) assay, Jerne hemolytic plaque and mice lethality assays were applied. In HA assay, the titer was significantly decreased in Nabumetone treatment groups (P< 0.001). In Jerne hemolytic plaque formation assay, there was a significant reduction (P< 0.001) in number of plaques in Nabumetone treated groups when compared with control. In mice lethality assay, there was a significant difference in mortality ratio of mice in control and Nabumetone treated groups (P< 0.001). Therefore, it is concluded that Nabumetone suppresses the humoral immune response in mice.
Highlights
Nabumetone is a non-acid pro-drug approved by the Food and Drug Administration authority in 1991
The titer was lowest in group treated with Nabumetone @28mg/kg.b.w when compared to the group treated with a 14mg/kg.b.w. dose (Figure 1)
There was a decrease trend in the production of plasma cells in Nabumetone treated mice
Summary
Nabumetone is a non-acid pro-drug approved by the Food and Drug Administration authority in 1991. It is a non-steroidal anti-inflammatory drug used in conditions such as rheumatoid arthritis, osteoarthritis, and any other disease associated with pain. Nabumetone is derived from 1-naphthyl acetic acid and inhibits the cyclooxygenase enzymes (Hassan et al, 2004). It belongs to the 2.6-substituted naphthyl alkaline class of nonsteroidal anti-inflammatory drugs, and 6methoxy 2-naphthyl acetic acid is its active metabolite which is mainly responsible for its pharmacological action as this active metabolite
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