Effect of music rhythm magnetic field on long-term potentiation of hippocampal Schaffer-CA1 synapse plasticity

Abstract

Music and magnetic fields both play important regulatory roles in brain learning and memory. The present study aimed to investigate the effects of music rhythmic magnetic fields at different frequencies on long-term potentiation (LTP) in the Schaffer-CA1 region of the hippocampus, with the goal of elucidating the molecular mechanisms underlying the impact of music rhythmic magnetic fields on brain learning and memory. Three different frequency music tracks were selected, including soothing track 1: Courante from the Baroque Suite, medium-frequency track 2: saxophone version of Liang Zhu, and high-frequency track 3: Johann Pachelbel’s music track Canon (trumpet version). Using an external sound card, power amplifier, and homemade coils, a time-varying magnetic field with a 2-mT music rhythm was produced to assess the effects of this magnetic field on LTP in the Schaffer-CA1 synapses of isolated rat hippocampal brain slices. The experimental results demonstrated that as the music frequency increased, the enhancing effect of the music rhythmic magnetic field on hippocampal synaptic plasticity LTP gradually intensified. Thus, high-frequency music rhythmic magnetic fields may offer a more effective means of enhancing LTP.