Abstract
Type 2 diabetes is associated with bad health consequences. The current study focused on the effect of Moringa olifera (MO) extract on some metabolic and biochemical parameters in induced type 2 diabetic albino rats. Twenty-eight albino male rats were selected and randomly divided into 4 groups. The control rats fed on a standard balanced diet and the second group fed standard balanced diet and gavaged with MO extract 50 mg/kg b.wt. The third group was a diabetic group that was induced to type 2 diabetes by high dietary fat for 8 weeks followed by streptozotocin (STZ) 25 mg/kg intraperitoneal (i.p.) while the fourth group was induced to type 2 diabetes and gavaged with MO extract 50 mg/kg b.wt. Treatment was continued for 4 weeks and, final body weight was recorded. Serum Lipid Profile, insulin resistance, super oxide dismutase (SOD), tumor necrosis factor alpha (TNF-α), resistin and liver enzymes were determined. Histopathology to hepatic tissue was also done. Results revealed a significant reduction in final body weights of diabetic rats than control. Serum lipid profile was deteriorated in the diabetic group. Insulin resistance, TNF-α, resistin and liver enzymes were significantly upregulated (P<0.05) in the diabetic rats than control while SOD was significantly reduced (P<0.05). Liver histopathology showed diffuse hazy vacuolation with leukocytic infiltration in the diabetic group and estrogen receptor (ER) immunostaining was significantly declined in diabetic group. All these changes were ameliorated with MO extract administration to diabetic rats. MO extract has a potential preventive effect against metabolic and biochemical alterations of type 2 diabetes.
Highlights
Type 2 diabetes is widely spread worldwide disease (Shaw et al, 2010).It is closely associated with insulin resistance and obesity (Guilherme et al, 2008).This disease is characterized by impairments in physiological body processes such as altering pancreatic function and secretion as well as metabolic disorders including glucose, protein and lipid (Tabak et al, 2009)
The present study investigated the therapeutic potential of Moringa olifera (MO) in counteracting the adverse consequences of Type 2 diabetes in Albino rats
The reduction of final body weight was attributed to muscle wastages due to lack of glucose entry to cells as well as amino acids creating a biosynthetic deficit in muscles(Wong and Tzeng, 1993).The administration of MO extract 50 mg/kg to diabetic rats significantly promoted this weight loss
Summary
Type 2 diabetes is widely spread worldwide disease (Shaw et al, 2010) It is closely associated with insulin resistance and obesity (Guilherme et al, 2008). This disease is characterized by impairments in physiological body processes such as altering pancreatic function and secretion as well as metabolic disorders including glucose, protein and lipid (Tabak et al, 2009). This disease is characterized by hyperglycemia and dyslipidemia (Guo et al, 2018; Vinson and Zhang, 2005). The later causes dramatic perturbations in the liver (Loria et al., 2013), eyes (Lutty, 2013), kidneys, bone tissue (Moseley, 2012), immune system (Wright et al, 2006), nervous tissue (Lue et al, 2012), and other parts of the body (King and Rosenthal, 2015)
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