Abstract
Milk protein-derived bioactive peptides could be used in human nutrition in both newborns and adults, since they are claimed to be health-improving components that can be used to reduce the risk of disease or to enhance certain physiological functions. This study investigated the effect of oral intake of milk protein concentrate (MPC) and milk protein concentrate hydrolysate (MPCH) on body weight, organ relative weight, and hematological parameters in alloxan-induced diabetes rats. The animals were divided into six major groups after stabilization of diabetes for one week. Diabetic and non-diabetic rats groups were received intra-gastric dose of MPC or MPCH (150mg/kg B.W) for six weeks. Feed treatment by MPC and MPCH significantly (<i>P</i><0.05) increased the final body weight of normal rats and improved the body weight of diabetic rats and significantly protective (<i>P</i><0.05) the liver, kidney, heart and lung of normal rats and reduced the fallers of these organs in diabetic rats. The diabetes groups treated by MPCH showed improvement in RBC, Hb, Ht and PLT values. Meanwhile WBC not affected. The oral intake of MPCH protected the normal range of Lymphocytes and S. Nutrophils in healthy and diabetic rats. The oral intake of MPCH caused significant (<i>P</i><0.05) decrease of Monocytes in diabetic and non-diabetic rats, while the oral intake of MPC had no affected on Monocytes of diabetic and non-diabetic rats. MPC and MPCH reduced the harmful effect of T2D on body weight, organs weights of rats, and improvement most hematological parameters of normal and diabetes rats.
Highlights
Diabetes is prevalent in about 3% to 5% of the population in industrialized countries
Our results showed that diabetic rats recorded a decrease in red blood cells counts (RBC) count, Hb content and Hct value.These rats suffered from anemia, which may be resulting from the toxic effect of alloxan used to induce diabetes in these rats
The diabetes groups treated by milk protein concentrate hydrolysate (MPCH) showed improvement in RBC, Hb, Ht and platelets count (PLT) values
Summary
Diabetes is prevalent in about 3% to 5% of the population in industrialized countries. Multiple metabolic disorders, including impaired lipid and lipoprotein metabolism, oxidative stress, subclinical inflammation, and vascular endothelial dysfunction, are common in DM [2].The major forms of diabetes, type 1 and type 2 diabetes, contribute at about 10 percent and 90 percent, respectively [3]. The worldwide incidence of type diabetes is increasing. It was estimated in 2000 that there were 171 million diabetics, while incidences for 2030 are estimated to reach 366 million people [4]. Type II diabetes (DM2) or non- insulin-dependent diabetes mellitus (NIDDM) is characterized by impaired insulin secretion or insulin resistance. DM2 is usually associated with obesity and hereditary disposition and it is the most common form of diabetes, affecting 90–95% of cases [5]. The consumption of dairy products has been associated with a reduction of the International Journal of Homeopathy & Natural Medicines 2019; 5(1): 18-29
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