Abstract
BackgroundMoonseed vine (Triclisia gilletii Staner) in the family Menispermaceae is a robust creeper of up to 10 cm diameter, of the lowland dense rain forest. In Ondo State, located in the South Western part of Nigeria, the plant which is usually called Peshe is used for the management of renal-related ailments. The present study was undertaken to explore the efficacy of Triclisia gilletii, a folkloric therapy in the management of renal-related ailment.ResultsPhenols, steroids, saponins, and flavonoids are present in the TGME with a total antioxidant capacity of (30.36 ± 1.90 (mg GAE/g extract), LD50 greater than 5000 mg/kg b.w., and in vitro anti-nucleation activity (iC50 = 7.09 mg/mL). Calcium oxalate stone formation as a result of oxalate from ethane-1,2-diol was evident by hypocalcemia, and further electrolyte imbalance and decreased glomerular filtration rate. The enhanced oxidative milieu in hyperoxaluria was evident by increased MDA and PC and decreased enzymatic and non-enzymatic antioxidants as well as renal membrane enzymes activities. The renal histopathological study further emphasized oxalate-induced damage and the ameliorative potential of TGME.ConclusionThe abnormal biochemical, redox electrolyte, membrane integrity, and histological alterations were attenuated by TGME which affirms its usage as nephroprotectant.
Highlights
Moonseed vine (Triclisia gilletii Staner) in the family Menispermaceae is a robust creeper of up to 10 cm diameter, of the lowland dense rain forest
The phytochemical screening of the aqueous methanolic leaf extract of Triclisia gilletii showed the presence of phenols (67.42 ± 0.69 mg gallic acid equivalent (GAE)/g extract), Turbidity (620 nm)
Increased MPO activity in ethane1,2-diol-administered animals in this study proves that inflammation accompanies stone formation, and the elevation in the creatinine and urea levels could be due to damage in the kidney tubules [48] as established by the marked changes in MPO activity
Summary
Moonseed vine (Triclisia gilletii Staner) in the family Menispermaceae is a robust creeper of up to 10 cm diameter, of the lowland dense rain forest. The present study was undertaken to explore the efficacy of Triclisia gilletii, a folkloric therapy in the management of renal-related ailment. Ethane-1,2-diol popularly known as ethylene glycol (EG) can induce calcium oxalate (CaOx) kidney stones, inflammation, and renal damage following oxalate saturation, supersaturation, nucleation, crystal growth, aggregation, crystal retention, and stone formation [6]. CaOx and high oxalate load cause oxidative damage and interstitial inflammation in the kidney, via production of reactive oxygen species, such as superoxide and hydrogen peroxide [7]. This leads to alterations in renal functional capacity
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
