Abstract
Preincubation of highly purified ox liver MAO with specific MAOI pargyline, iproniazid or tranylcypromine prevents qualitative alteration (“transformation”) in enzymatic properties of MAO after treatment of the enzyme with oxidized oleic acid (OOA). Pretreatment with pargyline or tranylcypromine of highly purified rat liver MAO prevents qualitative alteration in its enzymatic properties after incubation with Cu 2+ in aerobic conditions. Pretreatment of rats with iproniazid prevents appearance in liver mitochondria of histamine-, putrescine- and l-lysine-deaminating activity after parenteral administration of OOA into the rats. It is possible that MAOI may find new fields of application based on their property to prevent qualitative alteration in enzymatic properties of monoamine oxidases in some pathological states (e.g. those accompanied by accumulation of lipid peroxides in tissues).
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