Abstract
The effect of several monoamine oxidase (MAO) inhibitors and related compounds on guinea pig liver MAO and diamine oxidase (DAO) was examined in vitro and after administration to animals. The results showed that the MAO inhibitors possessing the hydrazine moiety inhibited both MAO and DAO, while two phenyl cyclopropylamine MAO inhibitors did not affect DAO. Hydrazine derivatives which did not block MAO retained a DAO inhibitory action. After administration of iproniazid to rats, DAO was inhibited long after the reported time for the drug to disappear from tissues; this finding suggests that the action of iproniazid on DAO, as well as on MAO, is “irreversible”.
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