Effect of modified Buyang Huanwu decoction combined with betahistine hydrochloride in the treatment of vertebral-basilar artery ischemic vertigo and its influence on hemorheological index

Abstract

Objective To observe the therapeutic effect of modified Buyang Huanwu decoction combined with betahistine hydrochloride in the treatment of vertebral-basilar artery ischemic vertigo and its influence on hemorheological index. Methods 80 patients with vertebral-basilar artery ischemic vertigo were randomly divided into observation group and control group, 40 cases in each group. The control group was given betahistine hydrochloride 12 mg, three times a day. The observation group was given modified Buyang Huanwu decoction on the basis of the control group, 4 weeks for a course. The DARS and DHI were measured before and after 4 weeks of treatment. The blood flow velocity was detected by transcranial Doppler ultrasonography, the difference of clinical curative effect between the two groups was compared. Results After treatment, the DARS and DHI scores of the observation group and control group were significantly decreased(t=14.716 and 5.258, 20.662 and 14.609, all P<0.01). The DARS and DHI scores in the observation group were significantly lower than those in the control group (t=3.644, 7.116, all P<0.05). After treatment, the average blood flow velocity of the vertebral artery, right vertebral artery and basilar artery in the observation group and the control group were significantly increased(t=11.216 and 7.447, 10.103 and 7.204, 11.303 and 6.642, all P<0.01). The average blood flow velocity of the vertebral artery, right vertebral artery and basilar artery in the observation group were significantly higher than those of the control group (t=4.405, 4.761, 5.824, all P<0.01). The total effective rate of the observation group was 95.00% (38/40), which was significantly higher than that of the control group (77.50%, 31/40), the difference was statistically significant (Z=-2.000, P<0.05). Conclusion Modified Buyang Huanwu decoction combined with betahistine hydrochloride is effective in the treatment of vertebro-basilar ischemic vertigo. It can improve the blood supply to the brain and relieve the symptoms of vertigo, which is worthy of popularization and application. Key words: Vertebrobasilar insufficiency; Modified buyang huanwu decoction