Abstract
On unanesthetized cats, we studied the effects of selective modulators of noradrenergic transmission on the activity of neurons of the cerebral motor cortex in the course of realization of an operant motor reflex to presentation of a complex of stimuli. These modulators were applied using microiontophoretic injections into sites of recording of impulse activity of cortical neurons within the zone of projection of the “working” forelimb. Applications of the α1 receptor agonist Mesaton resulted in significant suppression of background impulsation of the neurons and spiking within the interstimulus interval immediately during realization of the movement. Under the action of the α2 blocker yohimbine, opposite effects were observed. The activity of neurons increased within both background period and other examined time intervals. Mechanisms of the effects of modulation of noradrenergic transmission in the sensorimotor cortex are discussed.
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