Abstract
Aim. To evaluate an antihypertensive efficacy and influence on the arterial stiffness of 24-week treatment with metoprolol tartrate in patients with hypertension (HT) degree 1-2. Material and Methods. Patients with HT degree 1-2 (n=38) received therapy with metoprolol tartrate 50-200 mg QD for 24 weeks. Bifunctional daily blood pressure (BP) and electrocardiogramm monitoring with evaluation of central aortic pressure indicators as well as volume sphygmography were performed at baseline and after 24 weeks of therapy. Results. The 24-week therapy with metoprolol tartrate was effective in 47.2% of patients. Significant improvement in central aortic pressure [systolic BP decreased from 129.8±7.3 to 118.8±7.2 mm Hg; p 0.05). Significant reduction in arterial stiffness indexes was revealed with volume sphygmography: CAVI1 from 8.6 (8.1;9.6) to 8.0 (7.3;8.3); p<0.01; L-CAVI1 from 8.9 (7.6;9.9) to 7.9 (7.2;8.5), p<0.001. Conclusion. Metoprolol tartrate is an effective antihypertensive drug that improves the structural and functional properties of arteries.
Highlights
Significant improvement in central aortic pressure [systolic blood pressure (BP) decreased from 129.8±7.3 to 118.8±7.2 mm Hg; p
Significant reduction in arterial stiffness indexes was revealed with volume sphygmography: CAVI1 from 8.6 (8.1;9.6) to 8.0 (7.3;8.3); p
Low-dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness (IMT): main results from the Beta-Blocker Cholester ol-Lowering Asymptomatic Plaque Study (BCAPS)
Summary
Оценить антигипертензивную эффективность и влияние на артериальную ригидность 24-недельного применения метопролола тартрата у больных артериальной гипертензией (АГ) 1-2 степени. Кафедрой терапии МИ ПГУ Матросова Ирина Борисовна — к.м.н., доцент той же кафедры Томашевская Юлия Анатольевна — к.м.н., доцент той же кафедры Гусаковская Людмила Ивановна — к.м.н., ассистент той же кафедры Мельникова Евгения Александровна — аспирант той же кафедры. Практика показывает, что БАБ не могут рассматриваться как однородная группа, поскольку существуют и прямо противоположные сведения об улучшении показателей центрального давления в аорте при лечении отдельными представителями этого класса лекарственных средств [2]. Цель настоящего исследования состояла в оценке антигипертензивной эффективности и влияния на артериальную ригидность 24-недельного применения метопролола у больных АГ 1-2 степени
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