Effect of metiamide, a histamine H 2-receptor antagonist, on the development of gastric stress ulcers and acid secretion

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In normal and stressed rats with chronic gastric fistula small doses of metiamide (0.001–0.01 μM/kg) increased and doses of over 20 μM/kg decreased gastric acid secretion. In both these dose ranges of dosage metiamide suppressed the development of stress ulcers, most markedly in doses of 0.005 and 100 μM/kg. Intermediate doses had no such action. Only the anti-ulcer action of large doses of metiamide ran parallel to a reduction in acid secretion. Small doses of metiamide increased gastric secretion, but like larger doses, had a weak adrenergic action.