Effect of methanolic extract of Ventilago maderaspatana leaves on liver function markers and histopathology of liver tissue in streptozotocin-induced diabetic rats

Abstract

Aim: The liver is particularly vulnerable to oxidative stress brought on by hyperglycemia since it is the main tissue. In order to better understand how Ventilago maderaspatana leaf methanolic extract (MEVML) affects liver function markers and the histology of liver tissue in STZ-induced diabetic rats, this study looked into the hepatoprotective potential of MEVML. Method: A single STZ dose of 50 mg/kg body weight was given to the animals to cause diabetes. All of the experimental groups' serum was tested for levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), and urea content. Results: The results revealed a marked increase in the serum levels of urea, ALT, AST, ALP, and GGT activity. The results of MEVML treatment, however, were equivalent to those of glibenclamide treatment in that they led to a decline in the activity of ALT, ALP, AST, GGT, and urea content in the diabetic group of rats. Furthermore, diabetic rats' liver tissue showed considerable histological alterations. However, treatment with Ventilago maderaspatana methanolic leaf extract and glibenclamide considerably reduced these histological alterations. Conclusion: Overall, the findings of our study show that MEVML reduces liver function biomarkers and restores the architecture of hepatic tissue to reduce hepatic tissue damage under diabetes stress conditions.