Abstract
The oxidation of the biologically very important dimethyl sulfoxide system has been the subject of investigations. In present study Dimethyl sulfoxide (DMSO) can be oxidized to dimethyl sulfone by anodic electrolysis at a rotating platinum electrode. The polarographic method has been used to study qualitatively the effect of maxima suppressor gelatin, fuchsin, methyl red, thymol blue and supporting electrolyte HCl, CH3COOH on oxidation wave of DMSO. Polarographic oxidation of DMSO in 0.1 M HCl, 0.1 M CH3COOH solution using optimum concentration of fuchsin, methyl red, thymol blue as surface active substances is followed to determine the DMSO present in synthetic sample by calibration method. Wave analysis indicate the irreversible nature of the oxidation process which involves oxidation of dimethyl sulfoxide to dimethyl sulfone thereby increasing the oxidation state of sulphur from +2 to +4 state.
Highlights
The first quality that struck Dr Jacob about the Dimethyl sulfoxide (DMSO) drug was its ability to pass through membranes, an ability that has been verified by numerous subsequent researchers [1]
A scavenger of the free radicals that gather at the site of injury. This capability has been observed in experiments with laboratory animals [6] and in 150 ulcerative colitis patients in a double-blinded randomized study in Baghdad, Iraq [7]
The Committee of Clinical Drug Trials of the Japanese Rheumatism Association conducted a trial with 318 patients at several clinics using 90 percent DMSO and concluded that DMSO relieved joint pain and increased range of joint motion and grip strength, performing better in more recent cases of the disease [9]
Summary
The first quality that struck Dr Jacob about the DMSO drug was its ability to pass through membranes, an ability that has been verified by numerous subsequent researchers [1]. The Committee of Clinical Drug Trials of the Japanese Rheumatism Association conducted a trial with 318 patients at several clinics using 90 percent DMSO and concluded that DMSO relieved joint pain and increased range of joint motion and grip strength, performing better in more recent cases of the disease [9] It is employed widely in the former Soviet Union for all the different types of arthritis, as it is in other countries around the world. Dimethyl sulfoxide is colourlesss hygroscopic liquid, soluble in water, alcohol, benzene, acetone and chloroform It readily penetrates skin and other tissues being extensively tested as a means of carrying drugs and antitoxins into the blood by topical application, medicine (anti-inflammatory), veterinary medicine, plant pathology and nutrition, pharmaceutical products, metal - complexing agent. Polarographic oxidation of DMSO in 0.1 M HCl, 0.1 M CH3COOH solution using optimum concentration of fuchsin, methyl red, thymol blue as surface active substances is followed to determine the DMSO present in synthetic sample by calibration method
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