EFFECT OF MANGOSTEEN PEEL EXTRACT (Garcinia mangosteen) TO FIBROBLAST NUMBER AS PERIODONTAL DISEASE THERAPY

Abstract

Background: Periodontitis is one of the most common periodontal diseases in Indonesia. Inflammation and the bacteria that cause periodontitis can be treated by providing additional therapy in the form of a gel by the dentist. Mangosteen peel extract gel contains xanthones which function as antibacterial and anti-inflammatory so that it will accelerate the inflammatory phase. Purpose: This study aimed to determine the effectiveness of mangosteen peel extract gel in increasing the number of fibroblast cells in the healing process of periodontitis in Wistar rats (Rattus norvegicus).Material and Method: This research was an experimental laboratory design with a post-test-only design divided into 50% mangosteen peel extract gel group, 75% mangosteen peel extract gel group, 25% metronidazole gel group, and metronidazole plus gel group.Result: The research data were analyzed using the One Way ANOVA test and showed a significant value difference with a p=0.000 (p<0.05). However, in the inter-group test with Bonferroni post hoc, it was found that there was no significant difference between the 75% mangosteen peel extract gel group and 25% metronidazole gel group with a value of p = 0.709 (p>0.05).Conclusion: This study concludes that mangosteen peel extract gel effectively increases the number of fibroblast cells in the healing process of periodontitis.