Abstract
Nerve growth factor (NGF) contributes to the proliferation, differentiation and maintenance of the viability and functioning of peripheral and central neurons. At the Research Zakusov Institute of Pharmacology a dimeric dipeptide mimetic of the NGF loop 4 bis(monosuccinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2) was created. GK-2 activates PI3K/AKT and PLC-γ1 signaling cascades, without affecting MAPK/ERK, and appears to have procognitive properties. In the present study, we investigated the mnemotropic effects of GK-2 with a single intraperitoneal dose of 0.1, 0.5 and 5.0 mg/kg in the novel object recognition test in rats. GK-2 at a dose of 0.5 mg/kg statistically significantly improved the long-term memory of animals. In experiments on the rat hippocampal acute slices, we evaluated the effects of GK-2 on synaptic transmission and its plastic properties in the synaptic system Schaffer collaterals − CA1 pyramidal cell.
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