Abstract
Previous work has shown that carotid chemoreceptor (CC) inhibition increases cardiac output at rest in dogs with heart failure (HF). To translate this knowledge to humans, we recruited clinically stable HF patients (n=7; EF: 36±15%) and risk‐matched controls (CON; n=9; EF: 64±4%) from the Heart Function Clinic at the University of Alberta hospital, the Alberta HEART study, and from the general population. Ventilation, blood pressure, ECG, and aortic ultrasound were measured. Dopamine (DA) was infused at 2μg/min/kg to inhibit the CC. At rest, we found higher mean arterial pressure (98±14 vs 78±9mmHg; p=0.003) and higher total peripheral resistance index in CON (0.05±0.03 vs 0.04±0.01mmHg/mL/min/m2; p=0.01). These differences could be due to more frequent anti‐hypertensive treatment in HF. The DA decreased ventilation in HF (7.6±2.1 vs 6.8±1.7L/min; p=0.04) but not in CON (6.7±2.0 vs 6.7±2.0L/min; p=0.96). While there was no difference in cardiac output index (Q) at rest between groups (p=0.15), after DA infusion HF patients had higher Q (CON:1.7±0.5 vs HF:2.6±0.5L/min/m2; p=0.02). In HF, low‐dose DA inhibits the CC and increases resting cardiac performance. Funded by Heart and Stroke Foundation of Canada.
Published Version
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