Abstract
Long-chain free fatty acids (FFA) such as oleic and linoleic acids have been shown to inhibit the binding of T4 to binding proteins in serum (1–3). In a recent report, Chopra and coworkers (4) have presented evidence indicating tht circulating FFA, especially oleic acid, makes an important contribution to thyroid hormone binding inhibitor (THBI) activity found in sera of certain patients with nonthyroidal illnesses (NTI). Although oleic acid and linoleic acid are known to inhibit T4 binding to albumin (5), the effect of FFA on T4 binding to TBG, the major thyroid hormone-binding protein in serum, has not been studied directly. In the present study, we compared the effect of different FFA on the binding of T4 to pure TBG.
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