Effect of lisinopril on cardio-pulmonary function and 6 minutes walking distance in patients with hypertension

Abstract

Objective To compare the difference of antihypertensive efficacy, the result of heart and lung function test (CPET) and 6 minutes walking distance (6MWD) in hypertension patients with different angiotensin converting enzyme (ACE) gene polymorphisms. Methods 120 patients with hypertension were randomly divided into four groups: the control group treated with nifedipine zyban, perimental group of group A (II), group B ( ID ), group C ( DD ) treated with lisinopril tablets.The blood pressure control situation, the changes of the CPET and 6MWD results were compared in the four groups 3 and 6 months after treatment. Results After 3 months, there were no significant changes in blood pressure drop of the four groups, and the differences were no statistically significant among the four groups in the range of blood pressure drop(all P>0.05), the body mass, maximum oxygen uptake (VO2/kg) and 6MWD of the four groups were not significantly changed..After 6 months, the blood pressure of the four groups decreased, and there were no statistically significant differences between the four groups in the drop of blood pressure(all P>0.05), VO2/kg(mL): the control group(17.94±1.51)mL, group A(18.04±1.85)mL, group B(19.70±1.25)mL, group C(21.25±2.20)mL and 6MWD: the control group(448.66±50.26)m, group A(445.07±41.21)m, group B(488.56±55.66)m, group C(500.54±53.25)m.The improvement range of VO2/kg and 6MWD was group C>B>A(group B compared with group A: ct=12.01, P=0.03; group C compared with group B: dt=17.26, P=0.02), there were no statistically significant differences between the control group and group A(all P>0.05). Conclusion This study found no ACE genotype associated with the antihypertensive effects of lisinopril, but found improvement of CPET and 6MWD result in different groups, DD type is superior to the ID, the ID type is better than type II. Key words: Lisinopril; Hypertension