Effect of lipid- based encapsulated docetaxel nanoparticles- mediated B- mode ultrasound- guided focused low- level confocal dual pulse electrohydraulic shock wave therapy accompanied by intravenous methotrexate administration on early stage atherosclerosis

Abstract

Background and Aims: In atherosclerosis, local inflammation and associated macrophage activity can lead to foam cell- rich plaque formation. In this study, we developed an experimental confocal dual pulse shock wave therapy system, and investigated its effectiveness on foam cells density reduction, wherein diagnostic B- mode ultrasound is combined with sonodynamic therapy system, with a goal of increased safety.