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https://doi.org/10.1039/c39920001518
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Cite Publication Date: Jan 1, 1992 | |
 Citations: 124 |
An efficient synthesis of a homologous series of C8-linked pyrrolobenzodiazepine dimers is reported; compounds with an odd number of methylenes (n= 3 or 5) in the linker show a higher affinity for DNA, enhanced cross-linking efficiency, and are more cytotoxic compared with compounds with either n= 4 or 6.
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