Abstract
The effects of lignocaine hydrochloride on hypoxic pulmonary vasoconstriction in the presence and absence of nitrous oxide were examined during constant-flow perfusion of the left lower lobe. Lignocaine had no effect on lobar pulmonary vascular resistance during lobar ventilation with oxygen or 7% oxygen in nitrogen. The substitution of nitrous oxide for nitrogen diminished the hypoxic vasoconstrictor response, whilst the subsequent infusion of lignocaine during 7% oxygen in nitrous oxide increased the response to a value which was not significantly different from that produced by 7% oxygen in nitrogen alone.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.