Abstract
Objective To investigate the effect of lidocaine on expression of high mobility group box 1 ( HMGB1 ) mRNA in lung tissue in septic rats.Methods Fifty male Wistar rats weighing 200-250 g were randomly divided into 5 groups ( n ＝ 10 each):group sham operation( group S) ; group sepsis( group L) ; group low,medium and high dose lidocaine (groups LL1,LL2,LL3 ).Sepsis was induced by cecal ligation and puncture in groups L,LL1,LL2,LL3.Lidocaine 5,10 and 20 mg/kg were injected intraperitoneally at the end of operation,and at 1 and 2 h after operation in groups LL1,LL2 and LL3.Five animals in each group were sacrificed at 24 and 48 h after operation respectively.The lungs were removed for microscopic examination and determination of HMGB1 mRNA expression,MPO activity and activation of NF-cB.Results Sepsis up-regulated HMGB1 mRNA and increased MPO activity and activation of NF-κB and induced lung histo-pathological damage.Lidocaine attenuated the abovementioned sepsis-induced changes in a dose-dependent manner.Conclusion Lidocaine can attenuate sepsis-induced acute lung injury by down-regulating HMGB1 mRNA expression and inhibiting activation of NF-κB. Key words: Lidocaine; Sepsis; HMGB1 protein; RNA,messenger; Lung
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
