Effect of laparoscopic appendectomy on serum inflammatory factors and gastrointestinal function for patients with appendicitis

Abstract

Objective To investigate the effect of laparoscopic appendectomy on serum inflammatory factors and gastrointestinal function for patients with appendicitis. Methods Total of 155 patients with appendicitis underwent appendectomy who were selected in our hospital from January 2015 to March 2017 and were divided into the observation group (85 cases) and control group (70 cases) according to whether with laparoscopic surgery. The patients in observation group underwent laparoscopic appendectomy, and patients in the control group received open appendectomy. The levels of serum inflammatory factors and postoperative gastrointestinal function recovery indexes were analyzed before and after surgery in both groups, respectively. Results Preoperative serum levels of α-tumor necrosis factor (TNF-α) (t = 0.171, P = 0.865), C-reactive protein (CRP) (t = 0.556, P = 0.579), and amyloid A (SAA) (t = 0.317, P = 0.752) were not significantly different between the two groups. After operation, the serum levels of TNF-α (t = 2.604, P = 0.010), CRP (t = 6.061, P < 0.001) and SAA (t = 2.134, P = 0.034) in the observation group were significantly lower than those of the control group, with significant differences. The operation time of the patients in observation group was significantly longer than that of the control group (t = 6.703, P < 0.001), and the amount of bleeding (t = 14.168, P < 0.001), postoperative recovery time of bowel sounds (t = 3.859, P < 0.001), postoperative anal exhaust time (t = 3.374, P = 0.001), defecation time after operation (t = 2.994, P = 0.003) and postoperative hospitalization time (t = 6.917, P < 0.001) were significantly lower than those of the control group, with significant differences. Conclusions Compared with open appendectomy, laparoscopic appendectomy could effectively reduce postoperative inflammatory factors and promote gastrointestinal function recovery. Key words: Laparoscopic appendectomy; Open appendectomy; Appendicitis; Inflammatory factor; Gastrointestinal function