Abstract
Eight young men were maintained with a diet low in vitamin B6 for 2 months during which the taurine content of the urine was determined. Four of them were administered isoniazid (INH) (mean, 10 mg/kg/day) for the first month. Two of the 4 control subjects excreted less taurine at the end of 2 months than at the beginning. Additional signs of depletion were observed in one of them, subject M. The variability of taurine values was so large that depletion of the vitamin B6 stores of subject M can only be considered as a possibility. Either three of these subjects had not been given a low vitamin B6 diet long enough to deplete their stores or a vitamin B6 deficiency did not cause a decrease in urinary taurine in these subjects. The urinary taurine of the 4 men administered INH increased and remained above the starting values most of the time, even after the termination of INH treatment. The urinary taurine values for 2 of the 4 men responded much more rapidly to INH treatment than those of the other two. The lymphocyte counts in the blood of subject M and of the subjects treated with INH decreased.
Published Version
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