Abstract
The effects of intravitreal injected taurine and GABA on chicken ERG were studied.Taurine depressed the b-wave amplitude without affecting the a-wave. 6.0 μmoles of injected taurine/g retina was found to decrease the b-wave amplitude by more than 60%. 14.1 μmoles/g reduced the b-wave amplitude to 10% of its initial value. These concentrations are in the range of normal taurine contents of adult chicken retina. At the peak of b-wave inhibition, the injected taurine was concentrated in the inner synaptic layer and in the innermost part of the inner nuclear layer.Intravitreal injected GABA also depressed the b-wave amplitude. 20.0 and 29.5 μmoles of injected GABA/g retina were needed to reproduce the depressant effect of taurine. At a later stage, GABA increased a-wave amplitude and induced the appearence of a new corneal positive component of long latency (80-100 ms). Such changes were never seen with taurine.The results are discussed in relation to a possible role for taurine as a neurotransmitter or modul...
Published Version
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